[Ben Swenor]

Hi Gautam,

Did you grow any chips in low oxygen environment (hypoxic incubator) or was just based upon the COMSOL model sufficient to maintain low enough O2 levels on Chip?

Did you do any work looking at adding post-biotics on chip to see how that could be used to aid in a healthier vaginal microbiome?

Thanks!

[Ben Swenor]

@Stephen – My perspective would be that the model would then be caveated for that particular marker. My main reasoning being that it isn’t necessarily a flaw of the model, but a donor variability. It certainly could be a deficit of the model, but that is a large component of why having multiple donors for a given model is so critical. It allows us to account for this variability in response and determine whether it is an outlier or commonality. Additionally, for determining the criteria for a model, that is why organizations such as IQ MPS and others like it are so valuable. You have an independent group that sets a standard to be met that addresses the needs of that particular specialty and researchers on 3D in-vitro systems can then work towards them. With further understanding, the guidelines/requirements can be adjusted and improved upon, but it sets a precedent.